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[SSRM] A computational tool for unsupervised variable selection and patient stratification | Roberta Coletti
[SSRM] A computational tool for unsupervised variable selection and patient stratification | Roberta Coletti
4 May 2026 - 12:00 pm - 1:00 pm
Statistics and Risk Management Seminar
Department of Mathematics, NOVA MATH/FCT NOVA
Title: A computational tool for unsupervised variable selection and patient stratification
Speaker: Roberta Coletti, NOVA Math
Date | Time: May 04, 2026 | 12:00
Location: VII-1.11
Teams: https://teams.microsoft.com/meet/36124291051668?p=9wzuxJVsdpJQkGb9ww
Abstract: In this study, we developed TRIM-IT, a computational framework for data-driven patient stratification and biomarker discovery based on high-dimensional omics data. To address the challenges associated with high dimensionality, TRIM-IT first performs unsupervised variable selection to reduce data complexity while preserving dataset structure. The selected variables are then used for unsupervised clustering and downstream analyses to characterize the identified patient groups. Applied to glioblastoma transcriptomics data, TRIM-IT uncovered three distinct patient clusters associated with tumor histology, significantly different survival outcomes, and molecular profiles suggestive of potential biomarker candidates.
Short Bio: Roberta Coletti studied mathematics at Sapienza University of Rome. She completed a PhD in mathematics at the University of Trento, with a thesis on ordinary differential equation models of prostate cancer immunotherapy. Between 2021 and 2024, she was a researcher at the Center for Mathematics and Applications at NOVA University of Lisbon. Her work focuses on identifying molecular biomarkers for glioma cancer by analyzing large multi-omics datasets using statistical and machine learning methods.
Organizers: Isabel Natário and Mina Norouzirad and Marta Lopes
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This work is funded by national funds through the FCT – Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UID/00297/2025 (https://doi.org/10.54499/UID/00297/2025) and UID/PRR/00297/2025 (https://doi.org/10.54499/UID/PRR/00297/2025) (Center for Mathematics and Applications - NOVA Math)
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[MatHBioS] Seminar: Trait-variability and competitive dynamics: a pattern formation analysis, (Davide Cusseddu, Politecnico di Torino)
[MatHBioS] Seminar: Trait-variability and competitive dynamics: a pattern formation analysis, (Davide Cusseddu, Politecnico di Torino)
4 May 2026 - 4:15 pm - 5:15 pm
Room 2.23 - Building IX.
Abstract: Shigesada, Kawasaki, and Teramoto showed that introducing cross-diffusion effects in the spatial Lotka–Volterra competition model can destabilise the spatially homogeneous equilibrium and generate spatial patterns. In this seminar, I will present recent work in collaboration with Tommaso Lorenzi and Gaetana Gambino, in which we examined the effect of phenotype heterogeneity in competing populations. In particular, in our modelling framework, phenotype diversity affects movement and interactions between individuals. Motivated by cellular plasticity, we considered a regime of rapid phenotype switching and derived conditions for cross-diffusion- and phenotype-driven instabilities. Finally, I will present numerical simulations to illustrate the role of the phenotype distribution and its impact on competitive outcomes.
This Seminar is funded by national funds through the FCT – Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects \href{https://doi.org/10.54499/UID/00297/2025}{\textcolor{blue}{UID/00297/2025}} and \href{https://doi.org/10.54499/UID/PRR/00297/2025}{\textcolor{blue}{UID/PRR/00297/2025}} (Center for Mathematics and Applications
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[SOR] Nearest Correlation Matrices via Halfspace Projections | Yunier Bello-Cruz (Department of Mathematical Sciences at Northern Illinois University (NIU), IL, USA)
[SOR] Nearest Correlation Matrices via Halfspace Projections | Yunier Bello-Cruz (Department of Mathematical Sciences at Northern Illinois University (NIU), IL, USA)
6 May 2026 - 2:30 pm - 3:30 pm
Place: NOVA FCT, Sala 217D do Edif. Departamental
Title: Nearest Correlation Matrices via Halfspace Projections Speaker: Yunier Bello-Cruz, Department of Mathematical Sciences at Northern Illinois University (NIU), IL, USA Date | Time: May 6, 2026 | 14h30
Abstract:
The nearestcorrelation matrix problem asks for the closest positive semidefinite matrixwith unit diagonal to a given symmetric matrix G, measured in the Frobeniusnorm. We introduce HBAP (Halfspace Best-Approximation Projection), aprojection-based algorithm that approximates the positive semidefinite cone byintersections of supporting halfspaces and computes iterates via projectionsonto these simpler sets. At each iteration, HBAP constructs two halfspaces, asupporting halfspace for the positive semidefinite cone derived from thesquared-distance function, and a localization halfspace that enforces monotoneprogress, and projects the anchor point onto their intersection with theunit-diagonal affine subspace. Every iterate satisfies the unit-diagonal constraintby construction. We prove that HBAP is well defined and that the full sequenceconverges to the nearest correlation matrix to G. The projection subproblem ateach step admits a closed-form reduction to a 2X2 linear complementarityproblem, yielding an explicit update formula. Alternatively, the sameprojection can be computed via Dykstra-type inner iterations, for which wederive a natural splitting with fully explicit projectors.
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[SAL] Computing the k-universal transversal property | L. Soicher (Queen Mary University of London )
[SAL] Computing the k-universal transversal property | L. Soicher (Queen Mary University of London )
11 May 2026 - 2:00 pm - 3:00 pm
Room: to be announced Abstract: Algorithms and programs for computing the k-universal transversal property of a permutation group G are described. This property gives information about the regularity of a transformation semigroup <G,t> generated by G and a transformation t. New results obtained by the programs are also described.
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[SAn] Convergence of asymptotic systems in Cohen-Grossberg neural network models with unbounded delays | José J. Oliveira (Centro de Matemática (CMAT) & Departamento de Matemática, Escola de Ciências, Universidade do Minho)
[SAn] Convergence of asymptotic systems in Cohen-Grossberg neural network models with unbounded delays | José J. Oliveira (Centro de Matemática (CMAT) & Departamento de Matemática, Escola de Ciências, Universidade do Minho)
14 May 2026 - 3:00 pm - 4:00 pm
In this seminar, we present sufficient conditions for the convergence of asymptotic systems in non-autonomous Cohen-Grossberg neural network models that incorporate both infinite discrete time-varying and distributed delays. The main stability criterion is obtained by imposing conditions under which the non-delay terms asymptotically dominate the delay terms. As an application, we provide sufficient conditions ensuring that all solutions of a non-periodic neural network model with unbounded delays converge to a periodic function as time goes to infinity. A numerical example is presented to illustrate the effectiveness of the new results. This is a joint work with A. Elmwafy (PhD student) and César M. Silva of University of Beira Interior, Portugal.
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[SOR] Eigenvector-based acceleration strategies for gradient-type methods | Marcos Raydan (NOVA Math, Center for Mathematics and Applications, NOVA University Lisbon)
[SOR] Eigenvector-based acceleration strategies for gradient-type methods | Marcos Raydan (NOVA Math, Center for Mathematics and Applications, NOVA University Lisbon)
20 May 2026 - 3:00 pm - 4:00 pm
sala 204 do II.
Abstract:
Several strategies are described and analyzed to speed-up gradient-type methods when applied to the minimization of strictly convex quadratics and strictly convex functions. The proposed techniques focus on relaxing the traditional optimal step length associated with gradient methods, including the steepest descent (SD) and the minimal residual (MR) methods. Such a relaxation avoids the well-known negative zigzag effect and allows the iterates to move in the entire space which in turn implies that every so often the search direction approaches some eigenvector of the underlying Hessian matrix. The proposed speedups then rely on taking advantage of the properties of the Lanczos method once a search direction that approaches an eigenvector has been identified in order to accelerate the convergence towards the global minimizer. After analyzing the proposed strategies, we illustrate them on the global minimization of strictly convex functions.
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[SAn] The maximal function on spaces of homogeneous type, or adjacent dyadic cubes do good | Alina Shalukhina (Center for Mathematics and Applications (NOVA Math))
[SAn] The maximal function on spaces of homogeneous type, or adjacent dyadic cubes do good | Alina Shalukhina (Center for Mathematics and Applications (NOVA Math))
27 May 2026 - 2:00 pm - 3:00 pm
How do we control the sublinear Hardy–Littlewood maximal operator in non-Euclidean settings? By trading it for linear alternatives. In this talk, we show that the operator's boundedness on variable Lebesgue spaces over spaces of homogeneous type is entirely characterized by the uniform boundedness of specific averaging operators over dyadic cubes. Adapting Lars Diening's 2005 Euclidean framework, we expose the mechanics behind this clean reduction: Musielak–Orlicz spaces, Hytönen–Kairema adjacent grids, and the omnipresent principle of self-improvement.
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[SOR] Two-stage distributionally robust optimization with finite support | Agostinho Agra (CEMS.UL)
[SOR] Two-stage distributionally robust optimization with finite support | Agostinho Agra (CEMS.UL)
28 May 2026 - 11:00 am - 12:00 pm
Sala 1.11 do Edif. VII.
Abstract:
In this work, we study two-stage distributionally robust mixed-integer programs with uncertain parameters having finite discrete support. This setting is particularly attractive from a computational perspective because the DRO problem remains tractable and can be reformulated as a (possibly much larger) mixed-integer program, allowing the use of standard optimization technology. We propose an ambiguity set defined through a generalized optimal transportation problem. This formulation extends the classical Kantorovich ambiguity set, enabling the modeling of a wider range of practical situations while preserving useful structural properties. We analyze the main characteristics of this ambiguity set and discuss how they affect the structure of the resulting optimization problem.
Three solution frameworks are investigated. The first is the Benders-like method proposed by Bansal, Huang, and Mehrotra (2018). The second derives a single-stage formulation obtained by dualizing the transportation problem defining the ambiguity set. The third uses an epigraph formulation with dynamically generated optimality cuts in a row-and-column generation scheme. The approaches are evaluated on a distributionally robust location–transportation problem with uncertain demand. Computational results show that the relative performance of the approaches depends strongly on the characteristics of the ambiguity set: the dualization approach is simple and effective in the easiest instances, the row-and-column generation performs well when the ambiguity set approximates robust optimization, and the Benders-type method is preferable in the remaining settings.
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[SAn] On semi-linear higher-order impulsive coupled systems | Feliz Minhós (Centro de Investigação em Matemática e Aplicações (CIMA), Universidade de Évora)
[SAn] On semi-linear higher-order impulsive coupled systems | Feliz Minhós (Centro de Investigação em Matemática e Aplicações (CIMA), Universidade de Évora)
28 May 2026 - 3:00 pm - 4:00 pm
This talk presents a general theory for coupled systems, with regular and singular nonlinear fully differential equations of higher order, with generalized impulsive effects, depending on both variables and some derivatives. Two types of results are shown: first, an existence theorem, proved via fixed point theory. Secondly, we define a new type of coupled lower and upper solutions, and sufficient conditions to get the localization of a solution and some of its derivatives. The method is based on considering an auxiliary, truncated, and perturbated problem, whose solutions are also solutions of the initial problem. These results are applied to systems of singular Laplacians.
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